signaling receptor binding MHC protein binding Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. GO:0042287 major histocompatibility complex binding molecular_function major histocompatibility complex ligand Note that this term does not include binding to the antigen peptide bound to the MHC protein, for this also annotate to 'peptide antigen binding ; GO:0042605' or one of its children.