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    <!-- http://purl.obolibrary.org/obo/HP_0000252 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/HP_0000252">
        <rdfs:label>Microcephaly</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/HP_0007364"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/HP_0040195"/>
        <rdfs:comment>Head circumference is measured from just above the glabella (the most prominent point on the frontal bone above the root of the nose) to the most posterior prominent point of the occipital bone using a tape measure. Some standard charts are organized by centiles [Hall et al. [2007]], others by standard deviations [Farkas, [1981]]. It is important to add an indication of how far below the normal standard the head circumference is if an accurate assessment of this can be made. Microcephaly is an absolute term. The term relative microcephaly can be used when the head size centile is less than the centile for height, for example, head size at the 3rd centile with height at the 75% for age and sex. On prenatal ultrasound, microcephaly is diagnosed if the head circumference or the biparietal diameter is more than three standard deviations below the mean.</rdfs:comment>
        <oboInOwl:hasExactSynonym>Decreased size of cranium</oboInOwl:hasExactSynonym>
        <oboInOwl:hasBroadSynonym>Small skull</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasExactSynonym>Decreased circumference of cranium</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>UMLS:C0424688</oboInOwl:hasDbXref>
        <oboInOwl:hasBroadSynonym>Abnormally small head</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasDbXref>Fyler:4310</oboInOwl:hasDbXref>
        <oboInOwl:id>HP:0000252</oboInOwl:id>
        <oboInOwl:hasExactSynonym>Small head circumference</oboInOwl:hasExactSynonym>
        <oboInOwl:hasAlternativeId>HP:0001366</oboInOwl:hasAlternativeId>
        <oboInOwl:hasOBONamespace>human_phenotype</oboInOwl:hasOBONamespace>
        <oboInOwl:hasAlternativeId>HP:0005489</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>HP:0005485</oboInOwl:hasAlternativeId>
        <ns2:IAO_0000115>Head circumference below 2 standard deviations below the mean for age and gender.</ns2:IAO_0000115>
        <oboInOwl:hasBroadSynonym>Small head</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasDbXref>SNOMEDCT_US:271611007</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>Abnormally small skull</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Reduced head circumference</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>small cranium</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Decreased size of skull</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>Abnormally small cranium</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>small calvarium</oboInOwl:hasExactSynonym>
        <oboInOwl:hasAlternativeId>HP:0005497</oboInOwl:hasAlternativeId>
        <oboInOwl:hasBroadSynonym>Decreased size of head</oboInOwl:hasBroadSynonym>
        <oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/hp.oboInOwl#hposlim_core"/>
        <ns2:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/mondo.owl"/>
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    <!-- http://purl.obolibrary.org/obo/HP_0007364 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/HP_0007364">
        <rdfs:label>Aplasia/Hypoplasia of the cerebrum</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/HP_0040195 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/HP_0040195">
        <rdfs:label>Decreased head circumference</rdfs:label>
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