Tubular basement membrane disintegration HP:0005583 DIsruption and breaking up of the basement membrane of the tubules of the kidney. HP:0005577 UMLS:C1968618 Disintegration of the tubular basement membrane Throughout the rest of the nephron, tubule epithelial cells are attached to the tubular basement membrane that overlies the subjacent interstitial connective tissue. The disruption of cell-basement membrane adhesion results in loss of cell orientation, abnormal cell function, and can lead to tissue destruction. Abnormal tubular basement membrane morphology