disease has major feature Hyperparathyroidism parathyroid gland disease hyperparathyroidism COHD:133729 DOID:13543 EFO:0008506 Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes. ICD10:E21.3 ICD9:252.0 ICD9:252.00 MESH:D006961 MONDO:0001741 NCIT:C48259 SCTID:66999008 UMLS:C0020502 hyperparathyroidism