hypogonadism A disorder characterized by decreased function of the gonads. Clinical manifestations in both males and females include poor libido, infertility, and osteoporosis. Additional signs in males include erectile dysfunction, muscle atrophy, gynecomastia and increased abdominal fat. In females, additional signs include shrinking of the breasts and loss of, or failure to develop menstruation. DOID:1924 ICD9:253.4 MESH:D007006 MONDO:0002146 NCIT:C9227 SCTID:48130008 UMLS:C0020619 gonadotropin deficiency hypogonadotropism gonadal disease