disease caused by disruption of disease has basis in disruption of erythrocyte homeostasis anemia (disease) A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability. DOID:2355 EFO:0004272 HP:0001903 ICD10:D64.9 ICD9:285.8 ICD9:285.9 MESH:D000740 MONDO:0002280 NCIT:C2869 SCTID:271737000 anaemia anemia hematologic disease