has modifier pre-malignant neoplasm in situ carcinoma A malignant epithelial neoplasm which is confined to the epithelial layer without evidence of further tissue invasion. CIS COHD:433435 DOID:8719 Editor note: check pre-malignant vs malignant ICD10:D09.9 ICD9:230-234.99 ICD9:234.8 ICD9:234.9 ICDO:8010/2 MESH:D002278 MONDO:0004647 NCIT:C2917 SCTID:109355002 UMLS:C0007099 carcinoma in situ carcinoma, in situ, malignant epithelial tumor, in situ, malignant intraepithelial carcinoma non-invasive carcinoma stage 0 disease carcinoma high grade malignant neoplasm precancerous condition tumor grade 3, general grading system neoplastic, non-invasive