diabetes insipidus A disorder characterized by excretion of large amounts of urine, accompanied by excessive thirst. Causes include deficiency of antidiuretic hormone or failure of the kidneys to respond to antidiuretic hormone. It may also be drug-related. COHD:30968 DOID:9409 GARD:0011934 ICD10:E23.2 ICD9:253.5 MESH:D003919 MONDO:0004782 NCIT:C43263 SCTID:15771004 UMLS:C0011848 kidney disease