has modifier nephritis Mendelian disease hereditary nephritis A group of inherited conditions characterized initially by hematuria and slowly progressing to renal insufficiency. The most common form is the Alport syndrome (hereditary nephritis with hearing loss) which is caused by mutations in genes for type IV collagen and defective glomerular basement membrane. EFO:0004128 MESH:D009394 MONDO:0005334 SCTID:399340005 familial nephritis hereditary nephritis nephritis, familial inherited