disease has major feature Cerebral degeneration central nervous system disease neurodegenerative disease A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function. DOID:1289 EFO:0005772 Editor notes: DO treats this as two diseases ICD10:G31.9 ICD9:349.89 MESH:D019636 MONDO:0005559 NCIT:C4802 SCTID:80690008 brain degeneration central nervous system degenerative disorder central nervous system neurodegenerative disorder cerebral degeneration disease degenerative disease degenerative disorder of central nervous system neurodegenerative disease