autoimmune disease of musculoskeletal system autoimmune neuropathy skeletal system disease rheumatologic disorder mixed connective tissue disease DOID:3492 EFO:0007374 GARD:0007051 ICD10:M35.1 MCTD MESH:D008947 MONDO:0005854 MedDRA:10027754 Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus, scleroderma, and polymyositis. Some affected people may also have symptoms of rheumatoid arthritis. Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon ; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppresivedrugsmay help manage the symptoms. NCIT:C84892 Orphanet:809 SCTID:398049005 UMLS:C0026272 connective tissue disease overlap syndrome https://rarediseases.info.nih.gov/diseases/7051/mixed-connective-tissue-disease mixed collagen vascular disease sharp syndrome secondary interstitial lung disease in childhood and adulthood associated with a connective tissue disease systemic inflammatory disease associated with an acquired peripheral neuropathy overlapping connective tissue disease secondary glomerular disease