kidney failure uremia A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of renal insufficiency. Most uremic toxins are end products of protein or nitrogen catabolism, such as urea or creatinine. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms. DOID:4676 EFO:1001226 ICD10:N19 MESH:D014511 MONDO:0007008 MedDRA:10046369 SCTID:44730006 UMLS:C0041948 uremia of renal origin