congenital unilateral hypoplasia of depressor anguli oris Cayler cardiofacial syndrome Congenital unilateral hypoplasia of depressor anguli oris is a congenital anomaly, characterized by the unilateral hypoplasia/agenesis of the depressor anguli oris muscle, resulting in an asymmetric crying facies in neonatal period/ infancy (drooping of one corner of the mouth during crying) while eye closure, nasolabial fold and forehead wrinkling are symmetric. While it can be isolated, this anomaly is also seen in 22q11.2 deletion syndrome and can be accompanied by other major congenital anomalies of the cardiovascular system, as well as less frequently the musculoskeletal, cervicofacial, respiratory, genitourinary, and, rarely, endocrine systems. When isolated, the condition is cosmetically insignificant as the infant gets older (as the muscle does not contribute significantly to facial expression in childhood/ adulthood). Editor note: TODO check relationship to 22q11.2 deletion syndrome ICD10:Q87.0 ICD9:759.89 MONDO:0007443 OMIM:125520 Orphanet:1166 SCTID:51409009 asymmetric crying facies depressor anguli oris muscle, hypoplasia of facial paresis, partial, unilateral isolated asymmetric crying facies 22q11.2 deletion syndrome