disease has basis in dysfunction of MAFB multicentric carpo-tarsal osteolysis with or without nephropathy Carnevale canun Mendoza syndrome DOID:0111534 GARD:0003818 GARD:0013042 Idiopathic multicentric osteolysis is a very rare syndrome characterized by progressive loss of bone, usually the capsal and tarsal bones, resulting in deformity and disability, as well as chronic renal failure in many cases. The bone and renal disorders are sometimes associated with intellectual deficit and facial abnormalities. MCTO MESH:C567171 MONDO:0008152 OMIM:166300 Orphanet:2774 SCTID:766992008 UMLS:C2674705 https://rarediseases.info.nih.gov/diseases/3818/multicentric-osteolysis-nephropathy idiopathic multicentric osteolysis with or without nephropathy multicentric carpo-tarsal osteolysis with or without nephropathy multicentric carpotarsal osteolysis syndrome multicentric osteolysis nephropathy multicentric osteolysis, autosomal dominant osteolysis, hereditary, of carpal bones with or without nephropathy primary osteolysis syndromic renal or urinary tract malformation