disease has basis in dysfunction of GDF1 right atrial isomerism (disease) A visceral heterotaxy characterized by complete atrioventricular septal defect with a common atrium and univentricular AV connection, total anomalous pulmonary drainage, and transposition or malposition of the great arteries and may be associated with bilateral trilobed lungs, midline liver, asplenia and situs inversus affecting other organs that has material basis in homozygous mutation in the GDF1 gene on chromosome 19p12. DOID:0060856 GARD:0006795 HP:0011536 ICD10:Q20.6 Ivemark syndrome MONDO:0008832 MedDRA:10068335 OMIM:208530 Orphanet:97548 Polyasplenia RAI Vah, autosomal recessive asplenia syndrome asplenia with cardiovascular anomalies bilateral right-sidedness sequence heterotaxy, Visceroatrial, autosomal recessive polysplenia syndrome right atrial isomerism right isomerism splenic agenesis syndrome syndromic urogenital tract malformation genetic cardiac anomaly visceral heterotaxy syndromic renal or urinary tract malformation