disease has basis in dysfunction of HSD11B2 adrenal gland disease adrenal gland hyperfunction apparent mineralocorticoid excess 11 Beta-hydroxysteroid dehydrogenase type 2 deficiency 11-beta-hydroxysteroid dehydrogenase deficiency type 2 AME AME 1 Ame1 Apparent mineralocorticoid excess (AME) is a rare form of pseudohyperaldosteronism characterized by very early-onset and severe hypertension, associated with low renin levels and hypoaldosteronism. DOID:0090121 GARD:0000433 ICD10:E26.1 MESH:C537422 MONDO:0009025 NCIT:C131083 OMIM:218030 Orphanet:320 SCTID:703256004 UMLS:C2936861 UMLS:C3887949 UMLS:CN203981 Ulick syndrome ape apparent mineralocorticoid EXCESS apparent mineralocorticoid excess cortisol 11-Beta-ketoreductase deficiency cortisol 11-beta-ketoreductase deficiency https://rarediseases.info.nih.gov/diseases/433/apparent-mineralocorticoid-excess genetic hypertension