disease has basis in dysfunction of disease has feature SLC5A2 Glycosuria renal tubular transport disease familial renal glucosuria COHD:193170 DOID:9432 EFO:1001151 Familial Renal Glucosuria (FRG) is characterized by the presence of persistent isolated glucosuria in the absence of both generalized proximal tubular dysfunction and hyperglycemia. FRG is usually considered a benign entity as most patients are not affected by severe clinical consequences. Polyuria and enuresis and later a mild growth and pubertal maturation delay are the only manifestations that have been reported during a follow-up period of 30 years. Episodic dehydration and ketosis during pregnancy and starvation and an increased incidence of urinary tract infections have occasionally been reported in severe cases. FRG is caused by loss-of-function mutations in the gene SLC5A2 (16p11.2). GARD:0007548 GLYS Glys1 ICD10:E74.8 ICD9:271.4 MESH:D006030 MONDO:0009297 MedDRA:10038457 OMIM:233100 Orphanet:69076 SCTID:267430007 SGLT2 deficiency UMLS:C0017980 UMLS:C3245525 familial renal glucosuria glycosuria, renal https://rarediseases.info.nih.gov/diseases/7548/renal-glycosuria renal diabetes renal glucosuria renal glycosuria glucose transport disorder nephropathy secondary to a storage or other metabolic disease