disease has basis in dysfunction of SCARB2 action myoclonus-renal failure syndrome AMRF Action myoclonus-renal failure syndrome (AMRF) is a rare epilepsy syndrome characterized by progressive myoclonus epilepsy in association with primary glomerular disease. Patients present with neurologic symptoms (including tremor, action myoclonus, tonic-clonic seizures, later ataxia and dysarthria) that may precede, occur simultaneously or be followed by renal manifestations including proteinuria that progresses to nephrotic syndrome and end-stage renal disease. In some patients, sensorimotor peripheral neuropathy, sensorineural hearing loss and dilated cardiomyopathy are associated symptoms. EPM4 MONDO:0009699 OMIM:254900 Orphanet:163696 SCTID:764453009 action myoclonus-renal failure syndrome epilepsy, progressive myoclonic, 4, with or without renal failure myoclonus-nephropathy syndrome progressive myoclonic epilepsy type 4 primary glomerular disease progressive myoclonus epilepsy