disease has basis in dysfunction of AVPR2 nephrogenic syndrome of inappropriate antidiuresis ICD10:E22.2 MESH:C564491 MONDO:0010356 NSIAD Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a rare genetic disorder of water balance, closely resembling the far more frequent syndrome of inappropriate antidiuretic secretion (SIAD), and characterized by euvolemic hypotonic hyponatremia due to impaired free water excretion and undetectable or low plasma arginine vasopressin (AVP) levels. OMIM:300539 Orphanet:93606 SCTID:723440000 UMLS:C1845202 nephrogenic syndrome of inappropriate antidiuresis inherited renal tubular disease rare renal tubular disease