disease has basis in dysfunction of HBB autosomal recessive disease sickle cell anemia DOID:10923 EFO:1001797 GARD:0008614 Hb SC disease Hb-S/Hb-C disease Hb-SS disease without crisis HbS disease Hemoglobin S disease Hemoglobin S disease without crisis ICD10:D57 ICD10:D57.0 ICD10:D57.1 ICD10:D57.2 ICD10:D57.20 ICD9:282.6 ICD9:282.60 ICD9:282.63 MESH:D000755 MONDO:0011382 MedDRA:10040641 NCIT:C34383 OMIM:603903 Orphanet:232 Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur. UMLS:C0002895 drepanocytosis hemoglobin SC disease sickle cell anemia sickle cell disease sickle-cell/Hb-C disease without crisis sickling disorder due to Hemoglobin S rare disorder with congenital hypogonadotropic hypogonadism sickle cell disease and related diseases rare hereditary disease with avascular necrosis hematological disorder with renal involvement