disease has basis in dysfunction of NR3C2 pseudohyperaldosteronism type 2 Hypertension due to gain-of-function mutations in the mineralocorticoid receptor is a rare genetic hypertension characterized by a familial severe hypertension with an onset before age 20 years, associated with suppressed plasma renin and low aldosterone levels in the presence of low or normal levels of the mineralocorticoid aldosterone, that is highly resistant to antihypertensive medication. During pregnancy, there is a marked exacerbation of hypertension, accompanied by low serum potassium levels and undetectable aldosterone levels, but without signs of preeclampsia, requiring early delivery. ICD10:I15.1 MESH:C565359 MONDO:0011517 OMIM:605115 Orphanet:88660 SCTID:766937004 UMLS:C1854631 early-onset hypertension with exacerbation in pregnancy hypertension due to gain-of-function mutations in the mineralocorticoid receptor hypertension, early-onset, autosomal dominant, with Severe exacerbation in pregnancy hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy genetic hypertension hypertension, pregnancy-induced