disease has basis in dysfunction of TSHR hyperthyroidism familial hyperthyroidism due to mutations in TSH receptor Familial non-autoimmune autosomal dominant hyperthyroidism (FNAH) is a rare hyperthyroidism characterized by mild to severe hyperthyroidism, presence of goiter, absence of features of autoimmunity, frequent relapses while on treatment and a positive family history. GARD:0002858 ICD10:E05.8 MESH:C563786 MONDO:0012203 Nonautoimmune hyperthyroidism OMIM:609152 Orphanet:424 UMLS:C1836706 familial non-immune hyperthyroidism hyperthyroidism, NONAUTOIMMUNE hyperthyroidism, Nonautoimmune, autosomal dominant hyperthyroidism, congenital Nonautoimmune resistance to thyroid stimulating hormone toxic thyroid hyperplasia, autosomal dominant genetic hypertension