disease has basis in dysfunction of CFHR5 C3 glomerulonephritis CFHR5 deficiency Glomerulonephritis characterized by C3 accumulation with little or absent deposition of immunoglobulin, in the absence of ultrastructural electron-dense transformation seen in dense deposit disease. ICD10:N00.5 MONDO:0013892 NCIT:C123043 OMIM:614809 Orphanet:329931 UMLS:C3553720 UMLS:C4055342 UMLS:CN187045 complement-mediated membranoproliferative glomerulonephritis non-immunoglobulin-mediated membranoproliferative glomerulonephritis