Mendelian disease arthrogryposis multiplex congenita AMC Arthrogryposis multiplex congenita (AMC) is a group of disorders characterized by congenital limb contractures. It manifests as limitation of movement of multiple limb joints at birth that is usually non-progressive and may include muscle weakness and fibrosis. AMC is always associated with decreased intrauterine fetal movement which leads secondarily to the contractures. Arthromyodysplasia congenita GARD:0000777 Guerin-Stern syndrome Guérin-Stern syndrome ICD10:Q74.3 MONDO:0015168 MedDRA:10051643 OMIMPS:617468 Orphanet:1037 Otto syndrome Rossi syndrome amyoplasia congenita congenital amyoplasia congenital arthromyodysplasia fibrous ankylosis of multiple joints multiple congenital arthrogryposis myodysplasia myodystrophia fetalis deformans rocher-Sheldon syndrome arthrogryposis syndrome