synostosis craniosynostosis CSO Craniosynostosis is defined as the premature fusion of one or more cranial sutures leading to secondary distortion of skull shape resulting in skull deformities with a variable presentation. Craniosynostosis may occur in an isolated setting or as part of a syndrome. DOID:2340 GARD:0006209 ICD10:Q75.0 MESH:D003398 MONDO:0015469 MedDRA:10048907 MedDRA:10049889 NCIT:C84655 OMIMPS:123100 Orphanet:1531 UMLS:C0010278 craniosynostosis syndrome premature closure of cranial sutures dysostosis of genetic origin cranial malformation