rare head and neck malformation macroglossia GARD:0003342 ICD10:Q38.2 MESH:D008260 MONDO:0015496 MedDRA:10025391 Orphanet:156207 The presence of an excessively large tongue, which may be congenital or may develop as a result of a tumor or edema due to obstruction of lymphatic vessels, or it may occur in association with hyperpituitarism or acromegaly. It also may be associated with malocclusion because of pressure of the tongue on the teeth. (From Jablonski, Dictionary of Dentistry, 1992) UMLS:C0024421 enlarged tongue giant tongue genetic head and neck malformation rare maxillo-facial surgical disease