disease caused by disruption of disease has basis in disruption of mitochondrial translation mitochondrial oxidative phosphorylation disorder due to nuclear DNA anomalies mitochondrial disorder due to a defect in mitochondrial protein synthesis COXPD ICD10:E88.8 MONDO:0018157 Orphanet:35696 UMLS:CN227273 combined OXPHOS defect combined OXPHOS deficiency combined oxidative phosphorylation defect mitochondrial disease