renal tubular transport disease pseudohypoaldosteronism An inherited or acquired disorder of electrolyte metabolism, characterized by the inability of the renal tubules to respond to aldosterone. It is manifested by hyperkalemic metabolic acidosis, urinary salt wasting, normal or increased aldosterone secretion and normal glomerular filtration rate. DOID:4479 ICD9:255.8 MESH:D011546 MONDO:0018638 NCIT:C85034 Orphanet:444916 SCTID:77098009 UMLS:C0033805