syndromic visceral malformation syndromic developmental defect of the eye orofacial clefting syndrome syndromic urogenital tract malformation other syndrome with a central nervous system malformation as major feature syndrome with limb duplication, polydactyly, syndactyly, and/or hyperphalangy genetic otorhinolaryngologic disease Meckel syndrome DOID:0050778 GARD:0003436 ICD10:Q61.9 ICD9:753.1 ICD9:753.10 ICD9:759.89 MONDO:0018921 Meckel syndrome (MKS) is a rare, lethal, genetic, multiple congenital anomaly disorder characterized by the triad of brain malformation mainly occipital encephalocele, large polycystic kidneys, and polydactyly as well as associated abnormalities that may include cleft lip/palate, cardiac and genital anomalies, central nervous system (CNS) malformations, liver fibrosis, and bone dysplasia. Meckel-Gruber syndrome NCIT:C98978 OMIMPS:249000 Orphanet:564 SCTID:29076005 UMLS:C0265215 syndromic renal or urinary tract malformation familial cystic renal disease rare disease with glaucoma as a major feature cerebral disease with cataract lens shape anomaly nephropathy-associated ciliopathy genetic lethal multiple congenital anomalies/dysmorphic syndrome