Alport syndrome A genetic syndrome usually inherited as an X-link trait. It is caused by abnormalities in the COL4A5 gene. It affects males more often than females and is characterized by hematuria, progressive renal insufficiency, hearing loss, and ocular abnormalities. Alport deafness-nephropathy Alport's syndrome DOID:10983 ICD10:Q87.8 ICD10:Q87.81 MONDO:0018965 MedDRA:10001843 NCIT:C34842 OMIMPS:301050 Orphanet:63 UMLS:C1567741 hereditary nephritis syndromic genetic deafness disease of glomerular basement membrane renal disease with cataract lens shape anomaly