hypoalphalipoproteinemia LCAT deficiency ICD10:E78.6 LCAT (lecithin-cholesterol acyltransferase) deficiency is a rare lipoprotein metabolism disorder characterized clinically by corneal opacities, and sometimes renal failure and hemolytic anemia, and biochemically by severely reduced HDL cholesterol. MONDO:0018999 Orphanet:650 SCTID:49227001 lecithin-cholesterol acyltransferase deficiency nephropathy secondary to a storage or other metabolic disease metabolic disease with corneal opacity