disease has major feature CNS hypomyelination leukodystrophy COHD:374912 DOID:0050987 DOID:0060786 DOID:10579 Editor note: At this time DO has two classes 'hypomyelinating leukodystrophy' and one 'leukodystrophy' GARD:0006895 HLD ICD10:E75.2 ICD9:330.0 Leukodystrophies are a group of rare, progressive, metabolic, genetic diseases that affect the brain, spinal cord and often the peripheral nerves. Each type of leukodystrophy is caused by a specific gene abnormality that leads to abnormal development or destruction of the white matter (myelin sheath) of the brain. The myelin sheath is the protective covering of the nerve and nerves can't function normally without it. Each type of leukodystrophy affects a different part of the myelin sheath, leading to a range of neurological problems. MONDO:0019046 MedDRA:10024381 NCIT:C61253 OMIMPS:312080 Orphanet:68356 SCTID:192781003 UMLS:C0023520 UMLS:CN228461 https://rarediseases.info.nih.gov/diseases/6895/leukodystrophy hypomyelinating leukodystrophy hypomyelinating leukoencephalopathy leukodystrophy, hypomyelinating inherited neurodegenerative disorder