systemic disease amyloidosis (disease) A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands. COHD:432595 DOID:9120 EFO:1001875 Editor note: in DO this is classified as acquired metabolic, but contains familial subtypes HP:0011034 ICD10:E85 ICD10:E85.0 ICD10:E85.1 ICD10:E85.2 ICD10:E85.3 ICD10:E85.4 ICD10:E85.8 ICD10:E85.9 ICD9:277.3 ICD9:277.30 MESH:D000686 MONDO:0019065 MedDRA:10002022 NCIT:C2868 ONCOTREE:MIDDA Orphanet:69 SCTID:17602002 UMLS:C0002726 amyloid amyloid disease amyloidoses amyloidosis amyloidosis (disease) proteostasis deficiencies