disease_has_basis_in_development_of syndromic disease malformation syndrome with skin/mucosae involvement ectodermal dysplasia syndrome COHD:134757 DOID:2121 GARD:0006317 ICD9:757.31 MESH:D004476 MONDO:0019287 MedDRA:10010452 NCIT:C84683 OMIMPS:305100 Orphanet:79373 SCTID:8654005 The term ''ectodermal dysplasia'' defines a heterogeneous group of heritable disorders of the skin and its appendages characterized by the defective development of two or more ectodermal derivatives, including hair, teeth, nails, sweat glands and their modified structures (i.e. ceruminous, mammary and ciliary glands). The spectrum of clinical manifestations is wide and may include additional manifestations from other ectodermal, mesodermal and endodermal structures. UMLS:C0013575 congenital ectodermal defect ectodermal dysplasia ectodermal dysplasia (select examples) genetic epidermal appendage anomaly ectoderm