disease has feature Scleroderma rheumatologic disorder systemic autoimmune disease systemic disease with skin involvement scleroderma (disease) DOID:419 HP:0100324 MONDO:0019340 MedDRA:10039710 NCIT:C26746 Orphanet:801 Scleroderma Scleroderma is a rare autoimmune connective tissue disorder characterized by abnormal hardening of the skin and, sometimes, other organs. It is classified into two main forms: localized scleroderma and systemic sclerosis (SSc), the latter comprising three subsets; diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc) and limited SSc (lSSc). dermatosclerosis scleroderma