acquired metabolic disease acquired amyloid peripheral neuropathy non-familial hypertrophic cardiomyopathy non-familial restrictive cardiomyopathy amyloidosis (disease) AL amyloidosis AL Amyloidosis is a plasma cell disorder characterized by the aggregation and deposition of insoluble amyloid fibrils derived from misfolding of monoclonal immunoglobulin light chains usually produced by a plasma cell tumor. It usually presents as primary systemic amyloidosis (PSA) with multiple organ involvement and less frequently as primary localized amyloidosis (PLA) restricted to a single organ. GARD:0005797 ICD10:E85.9 Light chain amyloidosis Light-chain amyloidosis MESH:C531616 MONDO:0019438 MedDRA:10036673 Orphanet:85443 UMLS:C0268381 amyloidosis AL amyloidosis primary systemic primary AL amyloidosis primary amyloidosis primary amyloidosis (formerly) primary systemic AL amyloidosis primary systemic amyloidosis systemic AL amyloidsis secondary glomerular disease