syndromic disease malformation syndrome with skin/mucosae involvement rare developmental defect with connective tissue involvement systemic disease genetic systemic or rheumatologic disease dermis elastic tissue disorder Ehlers-Danlos syndrome COHD:79145 Cutis hyperelastica DOID:13359 Danlos Disease, Ehlers Danlos disease Disease, Ehlers Danlos Disease, Ehlers-Danlos Dystrophia mesodermalis congenita ED syndrome EDS Ehler Danlos Syndrome Ehlers Danlos Disease Ehlers Danlos syndrome Ehlers-Danlos Disease Ehlers-Danlos syndromes Fibrodysplasia elastica generalisata GARD:0006322 Hereditary collagen dysplasia ICD10:Q79.6 ICD9:756.83 India rubber skin MESH:D004535 MONDO:0020066 MedDRA:10014316 Meekeren-Ehlers-Danlos syndrome NCIT:C34568 OMIMPS:130000 Orphanet:98249 SCTID:398114001 Syndrome, Ehlers-Danlos The Ehlers–Danlos syndromes (EDS) are a clinically and genetically heterogeneous group of heritable connective tissue disorders (HCTDs) characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. UMLS:C0013720 danlos ehlers syndrome elastic skin skin elastic genetic skin disease