rare male infertility due to adrenal disorder rare female infertility due to an adrenal disorder Cushing syndrome ACTH-independent Cushing syndrome Adrenocorticotropic hormone (ACTH) independent Cushing syndrome is a form of endogenous Cushing syndrome (CS) that may result from excess secretion of cortisol by either a unilateral and benign (adrenocortical adenoma: 55-60%) or malignant (adrenocortical carcinoma: 35-40 %) adrenocortical tumor or by bilateral adrenal secretion by macronodular adrenal hyperplasia (AIMAH), as an isolated disease or as part of McCune-Albright syndrome (MAS), or by primary pigmented nodular adrenocortical disease (PPNAD), as an isolated disease or as part of Carney complex (CNC). ICD10:E24.8 MONDO:0020529 Orphanet:99893 UMLS:CN207429 adrenal Cushing syndrome adrenocorticotropic hormone-independent Cushing syndrome corticotropin-independent Cushing syndrome