disease caused by disruption of disease has basis in disruption of Ras protein signal transduction disease or disorder RASopathy EFO:1001502 MONDO:0021060 Orphanet:536391 Ras protein signal transduction disease The RASopathies are developmental syndromes caused by germline mutations (or in rare cases by somatic mosaicism) in genes that alter the Ras subfamily and mitogen-activated protein kinases that control signal transduction. disorder of Ras protein signal transduction disease of signal transduction