has role has_role has role material entity material entity biomarker role biomarker https://en.wikipedia.org/wiki/Biomarker_(cell) The NIH Biomarkers and Surrogate Endpoint Working Group defined a biomarker as “A characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention” (https://pubmed.ncbi.nlm.nih.gov/11240971/). However, the definition of 'characteriistc' is unclear, so we do not use the exact definintion in the ontology. https://en.wikipedia.org/wiki/Biomarker Yingtong Liu, Anthony Huffman, Oliver He https://en.wikipedia.org/wiki/Biomarker_(medicine) A material entity that has a measurable quality or process profile(s), which can be used as an indicator of an underlying biological state or identity.