part_of part of part of has_part has part has part deep_to superficial_to develops_from develops from develops from has developmental contribution from has developmental contribution from composed primarily of immediate transformation of material entity material entity skin epidermis dermis A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO] AAO:0000128 BTO:0000294 CALOHA:TS-2076 Consider adding a layer-of-skin grouping class for all skin layers EFO:0000953 EMAPA:17527 EV:0100154 FMA:70323 GAID:1321 MA:0000152 MAT:0000153 MESH:D020405 MIAA:0000153 TAO:0001119 UBERON:0002067 UMLS:C0011646 VHOG:0000108 When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG] XAO:0000217 ZFA:0001119 dermal uberon corium cutis The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]. vertebrate dermis hypodermis skin of body neural crest connective tissue mesoderm-derived structure ectoderm-derived structure future dermis structure with developmental contribution from neural crest collection of collagen fibrils integumentary system layer