leukemia acute leukemia A leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. These lymphocytes (acute lymphocytic leukemia [ALL]) or myeloid cells (acute myelocytic leukemia [AML]) proliferate abnormally, replacing normal marrow tissue and hematopoietic cells and inducing anemia, thrombocytopenia, and granulocytopenia. DOID:12603 DOID:12621 ICD10CM:C95.0 ICD10CM:C95.00 ICD9CM:208.0 NCI2009_04D:C9298 NCI:C9300 OMIM:308960 SNOMEDCT_US_2015_03_01:154599000 SNOMEDCT_US_2015_03_01:188763007 SNOMEDCT_US_2015_03_01:24072005 SNOMEDCT_US_2015_03_01:91855006 Stem cell Leukemia Stem cell leukaemia UMLS_CUI:C0085669 UMLS_CUI:C1378511 disease_ontology