spleen AAO:0010395 An organ involved in red blood cell filtration and immune response.[AAO] BTO:0001281 CALOHA:TS-0956 EFO:0000869 EMAPA:18767 EV:0100055 FMA:7196 GAID:1289 In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve in case of hemorrhagic shock, especially in animals like horses (not in humans), while recycling iron It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells MA:0000141 MAT:0000085 MESH:A15.382.520.604.713 MIAA:0000085 Neither hagfish nor lampreys possess what might be considered a discrete and condensed spleen. Hagfish possess dispersed lymphoid tissue within the submucosa of the intestine (96) associated with the portal vein (97), whereas lymphoid tissue is associated with the typhlosole portion of the intestine in lampreys (96) OpenCyc:Mx4rvVjgw5wpEbGdrcN5Y29ycA TAO:0000436 UBERON:0002106 UMLS:C0037993 VHOG:0000120 With the advent of clonal selection, the accumulation and segregation of T and B cells in specialized organs for antigen presentation became necessary, and indeed the spleen is found in all jawed vertebrates, but not in agnathans or invertebrates.[well established][VHOG] XAO:0000328 ZFA:0000436 galen:Spleen lien lienal splenic the organ that functions to filter blood and to store red corpuscles and platelets uberon hemopoietic organ immune organ digestive system element abdominal viscera