http://identifiers.org/pubmed/12700248 Can be analysed using flux balance analysis [http://identifiers.org/biomodels.kisao/KISAO_0000437]. The constraint-based modeling procedure does not strive to find a single solution but rather finds a collection of all allowable solutions to the governing equations that can be defined (a solution space). The subsequent application of additional constraints further reduces the solution space and, consequently, reduces the number of allowable solutions that a cell can utilize. constraint-based model