part of has part peptidyltransferase activity translation Wikipedia:Translation_(genetics) The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. protein translation GO:0006416 GO:0006453 GO:0043037 Reactome:R-HSA-72766 translational initiation translational elongation translational termination macromolecule biosynthetic process protein metabolic process protein biosynthetic process