therapeutic uses has role alkylating agent chemical entity pharmacotherapy antineoplastic therapy alkylating agent therapy 2019-01-22T18:50:33Z NCIT:C223 alkylating drug therapy CHEBI:22333 anti-neoplastic alkylating agent therapy NCIT:C1590 treatment with alkylating medication antineoplastic alkylating agent therapy An antineoplastic agent that replaces hydrogen atom(s) in nucleophilic moieties with alky radical(s), hindering proper function. Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cancer cell growth. Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases. treatment with alkylating drug treatment with alkylating agent