therapeutic uses has role chemical entity angiotensin receptor antagonist pharmacotherapy receptor antagonist therapy RAAS inhibitor therapy angiotensin receptor blocker therapy 2020-06-04T17:31:52Z treatment with ARB treatment with angiotensin receptor antagonist treatment with angiotensin II receptor antagonist Treatment with a class of agents that act by selectively inhibiting angiotensin II receptor activation in the renin-angiotensin-aldosterone system. treatment with angiotensin II receptor blocker A pharmaceutical agent that selectively inhibits angiotensin II receptor activation in the renin-angiotensin-aldosterone system reducing production and secretion of aldosterone, amongst other actions. The combined effects result in reduction of blood pressure. It is primarily used for the reduction of proteinuria and the treatment of hypertension in cases where the patient is intolerant of ACE inhibitor therapy. ARB therapy Angiotensin II receptor antagonists bind to and block the activation of angiotensin II type 1 (AT1) receptors, thereby reducing production and secretion of aldosterone, amongst other actions. The combined effects result in reduction of blood pressure. Although this class of agents is also used in diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure, it is primarily used for the treatment of hypertension in cases where the patient is intolerant of ACE inhibitor therapy. CHEBI:61016 NCIT:C66930