therapeutic uses has role chemical entity loop diuretic pharmacotherapy diuretic agent therapy loop diuretic agent therapy http://orcid.org/0000-0001-7941-2961 Therapy with an agent that inhibits the function of the sodium-potassium-chloride (Na+, K+, Cl-) cotransporter system in the thick ascending limb of the loop of Henle, thereby inhibiting the reabsorption of sodium, potassium, and chloride ions. This leads to an increase in the excretion of sodium, potassium, chloride, calcium, magnesium, ammonium and water. 2020-11-17T11:00:00Z treatment with loop diuretic