nutrition intervention substrate reduction therapy 2025-06-02T09:56:13Z An example is Gaucher disease, in which SRT aims to reduce the influx of glucocerebroside or glucosylceramide (GLC) influx into the lysosome by inhibiting the GLC-synthase enzyme, resulting in a reduction of the amount of GLC present. This is in contrast to enzyme replacement therapy, which works by supplementing the deficient or defective acid beta glucosidase to break down GLC into glucose and ceramide, which accumulates in macrophages in the absence of acid beta glucosidase.PMID:27559188 A type of therapy used in metabolic diseases characterized by reduced activity of a metabolic enzyme. Substrate reduction therapy (SRT) aims to reduce the amount of substrate influx to that enyzme.