protein metabolic process cellular protein metabolic process protein metabolic process and modification The chemical reactions and pathways involving a protein. Includes protein modification. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. protein metabolism multicellular organismal protein metabolic process cellular protein metabolism GO:0044267 GO:0044268 GO:0006411 Reactome:R-HSA-392499 protein metabolism and modification Wikipedia:Protein_metabolism macromolecule metabolic process primary metabolic process